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Quiescent disease, characteristics and biomarker correlations

ECCO 2018

Quiescent disease in the first ten years after diagnosis

CD studies into long-term prognosis and disease course primarily describe steroid exposure, need for surgery or hospitalisations, and disease progression as characteristics of unfavourable outcomes. However, real-life data on long-term disease activity are lacking. Recent research aimed to define clusters of patients with different disease activity patterns in the population-based IBD South Limburg cohort [1].

In total, all CD patients from this cohort with at least ten years follow-up (age >18 years; diagnosed between 1991 and 2004) were included (n=432). The researchers found that during ten years follow-up after diagnosis, patients experienced 4.2 quarters of active disease on average. In contrast, 29.6% of patients were classified as quiescent, and among these 89.8% never received immunomodulators (IMM) or biologics. Ileocolonic disease location (odds ratio (OR) 0.45;...

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