The suggested correlation between appendectomy and UC was investigated in a meta-analysis; at the same time, possible confounding factors were analysed.
A systematic review and meta-analysis were performed in July 2017 using MEDLINE, EMBASE and the Cochrane library. Data from studies describing the influence of appendectomy on colectomy rate and risk of CRC and/or HGD were extracted from published reports. Exclusion criteria were patients <18 years, non-UC, and animal studies.
A total of 891 studies were collected, of which 13 studies evaluating 73,323 UC patients were included (appendectomy n=2,859). All studies except one were rated as poor quality. Overall, colectomy rate in appendectomised and non-appendectomised patients was not significantly different (OR 1.21, 95% CI 0.84-1.75).
Four of six studies demonstrated significantly longer disease duration, however, with a decreased use of steroids after appendectomy. A total of six studi...
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