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Genetic predisposition for gut barrier dysfunction

ECCO 2018

Barrier dysfunction is a primary defect in Crohn’s disease (CD). The dysregulated barrier may be explained by the influence of genetics. This was shown by Keita et al. in a study with monozygotic and dizygotic twins who were discordant for CD [16]. A significant increase was observed in gut paracellular permeability in healthy monozygotic twins. It was also demonstrated that the passage of E. coli K-12 could be a consequence of inflammation rather than representing a primary defect in itself.

A total of 15 twin pairs (monozygotic n=9, dizygotic n=6) and ten external controls were included. Healthy co-twins and CD twins displayed increased 51Cr-EDTA permeability at 120 min both with (P<0.001) and without acetylsalicylic acid (P<0.001) compared to the control group. The observed difference took place at 20 min with acetylsalicylic acid when healthy co-twins were compared with external controls (P<0.05). When stratified by zygosi...

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