Home > Psychiatry > ECNP 2020 > Role of the Microbiome > The gut-brain axis and obesity

The gut-brain axis and obesity

Presented By
Dr Harriët Schellekens, University of Cork, Ireland
Conference
ECNP 2020
Microbiota are able to modulate ghrelinergic signalling; there has been some translational evaluation of effects on obesity and the hypothalamic-pituitary-adrenal (HPA) axis with supplementation of the probiotic Bifidobacterium longum. However, more research is needed to assess whether Bifidobacterium longum can alter food reward signalling and food-motivated behaviour and whether microbiota are involved in aberrant food reward signalling in obesity [1]. The gut-brain axis plays a major role in regulating short- and long-term appetite, food reward, and the body’s metabolism, Dr Harriët Schellekens (University of Cork, Ireland) explained [1]. Ghrelin –the hunger hormone– is pivotal in the regulation of homeostatic energy balance, metabolism, and central regulation of appetite and reward mechanisms in haedonic eating behaviour [2]. Chronic and acute stress can increase ghr...


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