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New drugs for alcohol use disorder to focus on combination therapy

Presented By
Dr Hamid Noori, Max Planck Institute for Biological Cybernetics, Germany
Conference
ECNP 2020
When searching for effective therapeutic options for patients with alcohol use disorder (AUD), research should combine several compounds rather than focusing on a single compound [1]. According to Dr Hamid Noori (Max Planck Institute for Biological Cybernetics, Germany), AUD is characterised by multiscale complexity, which not only shows in the multitarget molecular action of ethanol but also in the diversity of neurochemical and functional response patterns, as well as the different patterns of alcohol abuse and its behavioural consequences. Neurochemistry has been used for decades by in vivo microdialysis to screen acute and chronic drug effects on brain chemistry. However, the effects are very local and do not necessarily relate to the complete system. “We need to realise that there is a large amount of data available; around 215,000 studies have used this technique. If we were able to use this data and convert it properly for each brain...


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