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Personalised medicine in depression: a realistic way forward?

Presented By
Prof. Brenda Penninx, Amsterdam UMC, the Netherlands
ECNP 2020
Depression is a heterogeneous disease with a complex underlying pathophysiology. For personalised medicine, it is necessary to identify clusters of more homogeneous patient groups. Based on data from the large NESDA cohort, researchers have identified 2 subpopulations according to symptomatology. Whether the underlying neurobiological basis differs between the 2 groups is yet to be identified in larger follow-up studies. Depression is a complex disease in which a plethora of brain abnormalities are involved which can be at a structural, connectivity, and functional activation level, as Prof. Brenda Penninx (Amsterdam UMC, the Netherlands) explained [1,2,3]. Depression also involves dysregulated stress systems and disrupted energy regulation signalling, which may explain an association between depression and obesity [4,5]. Recent genome-wide analysis studies have provided insights into the genetic basis of depression [6]. When we combine all this data, ther...

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