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Altered gene expression of endogenous opioid system after alcohol exposure in adolescent rodents

Presented By
Mr Fabio Bellia, University of Teramo, Italy
Conference
ECNP 2020
  The endogenous opioid system plays a key role in alcoholism. The different regulations of these genes are not only linked to the amount of alcohol consumed, but also to sex, as demonstrated in a rodent model. Therefore, the influence of sex in elucidating the mechanism of alcoholism should not be overlooked [1]. In alcohol use disorder, the endogenous opioid system genes seem to play a pivotal role [1]. For a better understanding of how alcohol consumption affects genes transcription, it is important to analyse when alcohol consumption occurs, especially in critical developmental periods such as adolescence. Mr Fabio Bellia (University of Teramo, Italy) and colleagues studied the potential effects of alcohol consumption in rats during adolescence on opioid system gene transcription in adulthood. A short-term selection of rats was performed in an intermittent-access ethanol-intake protocol to generate 2 lines of high- and low-et...


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