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No altered fractional anisotropy in ADHD

Presented By
Ms Christienne Damatac, Donders Institute for Brain- Cognition and Behaviour, the Netherlands
Conference
ECNP 2020
Altered fractional anisotropy (FA) was not associated with attention-deficit/hyperactivity disorder (ADHD) in a large, longitudinal study. Continuous monitoring of disease symptoms may be more sensitive to FA than diagnostic categories. Moreover, the right cingulum angular bundle (rCAB) may play a role in the severity of hyperactive-impulsive (HI) symptoms [1]. Although ADHD has been related to differences in white matter (WM) microstructure, much remains unclear about the nature of these WM differences and the clinical aspects of ADHD they reflect. In a large longitudinal cohort, Ms Christienne Damatac (Donders Institute for Brain- Cognition and Behaviour, the Netherlands) and her colleagues assessed the association between WM microstructure and symptom severity and the development of this association was investigated over time. Clinical and MRI data was obtained from 654 participants (322 were unaffected, 258 were...


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