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Predicting individual effectiveness of biologics in severe asthma

Presented By
Prof. Celeste Porsbjerg, Bispebjerg-Frederiksberg University Hospital, Denmark
ERS 2020
Choosing a biological treatment for asthma requires the presence of exacerbations or necessity of daily oral corticosteroids (OCS). The use of special predictors of the efficaciousness of different modes of action can help to tailor treatment [1]. “To diagnose severe asthma is actually the most challenging part of identifying patients for biological treatments,” said Prof. Celeste Michala Porsbjerg (Bispebjerg-Frederiksberg University Hospital, Denmark) [1]. As a first step, it is essential to distinguish difficult-to-treat asthma from severe asthma by systematically evaluating all factors that may contribute to poor asthma control like deficient adherence or untreated comorbidities [2-4]. A very recent study found that the systematic assessment of patients within a group of high-dose treated asthma revealed only 12% with severe asthma and 88% difficult-to-treat asthma, with a possibly substantial rate of overlap of patients suffering from severe...

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