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The role of chronic symptoms as early biomarkers of COPD development

Presented By
Dr James Allinson, Imperial College London, UK
Conference
ERS 2020
Research findings over the years have suggested that the presence of chronic symptoms is not directly associated with the development of airflow limitation. Their course over a patient’s life is rather unstable as they may appear, disappear, and reappear over the years. Dr James Allinson (Imperial College London, UK) discussed the available evidence on the role of symptoms in early COPD in his lecture at the ATS 2020 [1]. Formerly, GOLD 0 was a classification describing people with normal lung function, but the presence of chronic symptoms would indicate an increased risk of developing COPD [1,2]. Those symptoms were chronic chough and sputum, also referred to as chronic bronchitis/chronic mucus hypersecretion (CMH). CMH has been associated with poor outcomes like mortality or FEV1 decline in smokers with and without COPD [3,4]. “But definitely linking GOLD 0 with a subsequent development of airflow limitation has proven quite difficul...


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