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Stable long-term effects of deep brain stimulation in Parkinson’s disease

Conference
AAN 2021
Trial
CSP468 VA/NINDS, INTREPID
Long-term results of the CSP468 VA/NINDS trial demonstrated that deep brain stimulation (DBS) therapy had a significant and stable effect on motor function of patients with Parkinson’s disease, regardless of whether the globus pallidus interna (GPi) or the subthalamic nucleus (STN) were targeted. This is remarkable in view of the progressive nature of Parkinson’s disease. DBS of the GPi and STN are well-established therapies of Parkinson’s disease, but outcomes on the very long-term are lacking. At the AAN 2021 meeting, extended long-term outcomes – of up to 10 years in some cases – from the landmark CSP468 VA/NINDS multicentre, randomised-controlled trial (NCT01076452) were presented [1]. A subset of patients originally randomised to GPi or STN DBS and with visits completed at 2 years were followed for up to 10 years. Data included analyses at baseline (GPi...


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