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Autoimmune mechanisms implicated in Parkinson’s disease

Presented By
Dr Camille Michaud, University of Montreal Hospital Research Centre, Canada
AAN 2021
Monocyte-derived dendritic cells from patients with Parkinson’s disease present a dysregulated cytokine profile. The subset of cytokines that is altered promotes T-cell polarisation towards autoimmune-related Th1/Th17 cells. The authors conclude that this data supports the hypothesis that autoimmune mechanisms may be implicated in Parkinson’s disease. One of the major hallmarks of Parkinson’s disease is inflammation. Furthermore, the Parkinson’s disease-related genes PINK1 and Parkin regulate the mitochondrial antigen presentation pathway. PINK1 aggregates on damaged mitochondria and recruits Parkin, thus triggering mitophagy. If PINK1 or Parkin are missing, mitochondrial-derived vesicles (MDV) may form. The mitochondrial antigens contained within the MDVs may be expressed at the cell surface. To better understand the processes taking place in the periphery in Parkinson’s disease, Canadian researchers investigated whether antigen-presenti...

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