Home > Haematology > EHA 2021 > Leukaemia > Reduced-intensity conditioning ASCT is effective in older patients with AML

Reduced-intensity conditioning ASCT is effective in older patients with AML

Presented By
Prof. Nigel Russell, Guy's Hospital, UK
Conference
EHA 2021
Trial
AML16; AML18
Two consecutive trials in older patients with acute myeloid leukaemia (AML) or high-grade myelodysplastic syndromes (MDS) showed improved efficacy results for allogeneic stem cell transplantation (ASCT) with reduced-intensity conditioning (RIC). Although >65% of older (i.e. >60 years) patients with AML can achieve a complete response (CR) with intensive chemotherapy, only 20% will survive to 5 years. Thus, interventions based on preventing relapse are a priority. Options include consolidation chemotherapy, maintenance therapy, and RIC ASCT, which has made ASCT with curative intent available for older patients. Patients who achieve a CR but remain minimum residual disease (MRD)-positive are known to have an adverse prognosis and are at a higher risk of relapse following RIC transplant [1,2]. Prof. Nigel Russell (Guy's Hospital, UK) discussed the outcomes of 2 consecutive, randomised trials for patients >60 years with AML or...


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