Home > Haematology > EHA 2021 > Thrombotic and Thrombocytopenic Disorders including COVID-19 related > Mechanisms of COVID-19 vaccine-induced thrombotic thrombocytopenia

Mechanisms of COVID-19 vaccine-induced thrombotic thrombocytopenia

Presented By
Prof. Andreas Greinacher, Universitätsmedizin Greifswald, Germany
Conference
EHA 2021
Vaccine-induced thrombotic thrombocytopenia (VITT) is caused by anti-PF4 autoantibodies, starting a procoagulatory cascade, eventually leading to a highly prothrombotic state, amplification, and loss of control. This is likely triggered by a response to free proteins and the preservative EDTA in the vaccine. Since February 2021, several cases of unusual thrombotic events in combination with thrombocytopenia were observed in people who received AstraZeneca’s  nCov-19 vaccine. Prof. Andreas Greinacher (Universitätsmedizin Greifswald, Germany) presented previously published and unpublished data on VITT [1]. The typical VITT pattern is development of thrombocytopenia, cerebral vein, and/or splanchnic vein thrombosis 4–20 days after vaccination with an adenoviral vector-based SARS-CoV-2 vaccine, strongly positive results for platelet factor 4 (PF4)/heparin IgG ELISA, and Fc-gamma receptor-mediated platelet activation in presence of PF4 [2–5]. The...


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