https://doi.org/10.55788/3d2f53d9
The selective sphingosine-1-phosphate (S1P) receptor modulator etrasimod was assessed for its potential benefits in treating adult patients with UC in the phase 3 ELEVATE UC 52 (NCT03945188) and ELEVATE UC 12 (NCT03996369) trials [1]. ELEVATE UC 52 had a so-called ‘treat-through’ design: the included 433 patients were randomised 2:1 to 2 mg of etrasimod or placebo and the co-primary endpoint was clinical remission at week 12 and week 52; patients who did not improve within the induction period were allowed to switch and be enrolled in the open-label extension study ELEVATE UC OLE (NCT03950232) at week 12. In ELEVATE UC 12, 354 adult patients were treated with 2 mg of etrasimod orally or placebo and the study was completed after 12 weeks with the primary endpoint being clinical remission, defined via the modified Mayo score (stool frequency subscore 0/1, rectal bleeding 0, endoscopic subscore of 0/1).
All participants were 16–80 years old, had moderate-to-severe UC, and a history of inadequate or loss of response to at least 1 treatment for UC, but not more than 2 biologics or 1 biologic and 1 JAK inhibitor. The demographics were well balanced across the different arms. On average, the disease duration was 7 years, about one-third of patients had extensive colitis, and the median Mayo score was 7. Between 51.7% and 61.1% of participants had a baseline endoscopic score of 3. Looking at prior treatment, 60% of participants were naïve and 40% were exposed; one-third was on concomitant steroids.
Clinical remission rates in ELEVATE UC 52 were statistically significant both at week 12 and week 52: 27% for etrasimod versus 7.4% for placebo and 32.1% for etrasimod versus 6.7% for placebo, respectively (P<0.001 for both comparisons). Also, key secondary endpoints like endoscopic improvement, symptomatic remission, and steroid-free remission were all positive. “There was not a single endpoint that was not met,” Prof. Séverine Vermeire (University Hospital Leuven, Belgium) summarised. In ELEVATE UC 12, both primary and secondary endpoints showed significant superiority of etrasimod over placebo.
“What I would like to highlight is that the treatment-emergent adverse events were overall balanced across the different groups,” Prof. Vermeire commented on the safety results, underlining that there was no signal in terms of serious or opportunistic infections whatsoever. She valued the safety profile consistent with previous trials.
“In both studies, treatment with etrasimod 2 mg daily resulted in clinically meaningful and statistically significant improvements in all pre-defined outcomes at week 12 and week 52,” Prof. Vermeire concluded.
- Sandborn WJ, et al. Etrasimod 2mg once daily as treatment for moderately to severely active ulcerative colitis: results from the phase 3 ELEVATE UC 52 and ELEVATE UC 12 trials. OP086, UEG Week 2022, 8–11 October, Vienna, Austria.
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Table of Contents: UEGW 2022
Featured articles
IBD in 2022
Fast recapture of response with ozanimod after withdrawal in UC
Ozanimod treatment prompted substantial response after failure of response to induction
Etrasimod shows advantage over placebo in UC
Etrasimod reduces adaptive immune cells in the periphery in UC
Favourable maintenance rates for risankizumab also in delayed responders with CD
IL-23 inhibition reduces inflammatory biomarkers in pre-treated UC
Maintained symptom control with mirikizumab in UC
Mirikizumab successfully resolves active histologic inflammation in UC
Upadacitinib for CD: remarkable efficacy in induction therapy
Sustained maintenance results with upadacitinib in UC
Another chance for TYK2 inhibition in UC
Small molecule obefazimod shows promise in UC
Pivotal results of etrolizumab for CD partly disappointing
Better results for vedolizumab in early CD
Some patients with limited CD may benefit from an early surgical intervention
Dose-interval of adalimumab might be prolonged in CD patients in stable remission
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Less ulcer bleeds early after H. pylori eradication in aspirin users
Dupilumab effective in paediatric patients with eosinophilic oesophagitis
Neoplasia in Barrett’s oesophagus: the earlier the intervention, the better the long-term outcome
Hepatology in 2022
Favourable pancreatitis outcomes with procalcitonin-based algorithm to guide antibiotic use
Portal hypertension is associated with poor prognosis in cirrhotic patients
Chances of transplant-free survival in PSC enhanced by colectomy with ileostomy
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