Home > Cardiology > ACC 2021 > Ischaemic Heart Disease > Moderate hypothermia not superior to mild hypothermia following out-of-hospital cardiac arrest

Moderate hypothermia not superior to mild hypothermia following out-of-hospital cardiac arrest

Presented By
Dr Michel Le May , University of Ottawa, Canada
Conference
ACC 2021
Trial
CAPITAL-CHILL
Among patients who had experienced an out-of-hospital cardiac arrest (OHCA), inducing moderate therapeutic hypothermia (cooling to 31°C) did not result in better neurological or mortality outcomes than inducing mild hypothermia (cooling to 34°C) in the CAPITAL CHILL trial [1]. While current guidelines for the management of patients who have experienced OHCA recommend targeted temperature management, it remains unclear what the optimal target temperature should be to achieve the most favourable outcomes. A pilot study of 36 patients suggested that better outcomes may be achieved by inducing hypothermia below the guideline-prescribed range of 32–34°C [2]. The CAPITAL-CHILL trial (NCT02011568), presented by Dr Michel Le May (University of Ottawa, ON, Canada), was the first randomised controlled trial to explore outcomes achieved by cooling OHCA patients to 31°...


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