Clopidogrel monotherapy associated with better net outcomes relative to aspirin monotherapy 6-18 months after PCI

The open-label HOST-EXAM study showed that clopidogrel monotherapy was associated with better net outcomes relative to aspirin in patients who were event-free for 6–18 months following percutaneous coronary intervention (PCI) with a drug-eluting stent (DES) over a 2-year follow-up period [1,2]. In patients who have undergone PCI, guidelines suggest 6–12 months of dual antiplatelet therapy (DAPT), typically with aspirin plus a P2Y12 inhibitor such as clopidogrel. After the initial 6–12 month period, lifetime aspirin monotherapy is recommended. Prof. Hyo-Soo Kim (Seoul National University Hospital, South Korea) and colleagues aimed to explore whether an alternative monotherapy could achieve superior clinical outcomes compared with aspirin. The primary endpoint was a composite of all-cause death, acute coronary syndrome including non-fatal MI, stroke, the need for revascularisation while under antiplatelet ...

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Posted on 9 July, 202129 July, 2021