Home > Haematology > EHA 2020 > Bench-to-Bedside Science from the Presidential Symposium > Unrecognised role of iron in neutrophil differentiation

Unrecognised role of iron in neutrophil differentiation

Presented By
Dr Bruno Galy, German Cancer Research Centre, Germany
Conference
EHA 2020
In Cre/Lox mouse models, functional disruption of iron regulatory proteins (IRPs) leads to halted differentiation of haematopoietic stem cells (HSCs) into granulocytes at later stages. Transcriptome analysis suggests a role for IRPs in cellular metabolism during neutrophil differentiation. The findings were presented by Dr Bruno Galy (German Cancer Research Centre, Germany) during the Presidential Symposium [1]. Using a conditional gene knock-out (KO) mouse model to disrupt IRPs, the research team reported that acute loss of IRPs resulted in microcytic anaemia and bone marrow aplasia, which was associated with a corresponding decrease of myeloid cell and erythrocyte counts in peripheral blood. Increased counts of stem and multipotent progenitor cells led to an enlargement of the stem cell compartment. Surprisingly, while common progenitors were amplified in the KO compared with the control mice, increased numbers of differentiated cells were not observed.


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