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Inflammation may change the course of Parkinson’s disease

Presented By
Prof. Vidar Gundersen, University of Oslo, Norway
EAN 2019
Inflammation may start early in Parkinson's disease (PD), long before motor symptoms occur, according to Prof. Vidar Gundersen (University of Oslo, Norway) in a plenary talk about the central theme of EAN 2019: “Neuroinflammation” [1]. In PD, microglia are activated and are present in dopamine neurons long before the accumulation of α-synuclein pathology. This implies that microglial activation probably contributes to the development of α-synuclein pathology [2]. Early activation of microglia has also been demonstrated in translocator protein (TSPO) PET imaging [3]. Both pro- and anti-inflammatory cytokines are activated, such as TNF and IL-1-beta. The pro-inflammatory cytokine IFN-gamma is also involved in inflammatory-induced neurodegeneration in PD [4]. Prof. Gundersen went on to explain how inflammation may contribute to dopamine neurodegeneration. He suggested that the adaptive immune system is involved in PD pathology and that PD might even be...

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