In an analysis of 64 brain donors (52 PDD, 12 DLB), multiple clinical and neuropathological differences between PDD and DLB were observed [1]. This result supports the hypothesis that PDD and DLB represent two different disorders. Compared to PDD patients, DLB patients had:
- shorter disease duration (P<0.001);
- older age at motor symptoms onset (P=0.022);
- less frequent tremor (P=0.017);
- no dyskinesia (P<0.001);
- less severe parkinsonism at the time of dementia (P<0.001);
- lower MMSE scores (P=0.006).
DLB patients took less levodopa, dopamine agonists, monoamine oxidase inhibitors, amantadine, and anticholinergics compared to PDD patients. Alzheimer’s disease neuropathology scores were significantly higher in DLB vs PDD (B-score P=0.018; C-score P=0.016).
- Holton J, et al. EAN 2019, O4119.
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Table of Contents: EAN 2019
Featured articles
Letter from the Editor
Alzheimer’s Disease and other Dementias
A necessary shift of focus to the earlier stages of Alzheimer’s
Antipsychotics increase mortality regardless of comorbidity
Epilepsy
Neuroinflammatory pathways as biomarkers and treatment targets
Long-term effect of recurrent febrile seizures
Migraine
The role of neurogenic inflammation in migraine
Multiple Sclerosis
Treating MS from disease onset
Randomised and observational studies comparing treatments
Autologous haematopoietic stem cell transplantation
Neuromuscular Disorders
Parkinson's Disease and other Movement Disorders
Inflammation may change the course of Parkinson’s disease
Opicapone: follow-up on the BIPARK I and II trials
Epigallocatechin gallate does not modify MSA progression
Stroke
Thrombo-inflammation during ischaemia/reperfusion
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