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No disease-modifying effect of levodopa/carbidopa in Parkinson’s

EAN 2019
Determining disease-modifying qualities of levodopa could result in a rationale for initiating treatment earlier in the course of PD. In a double-blind, placebo-controlled, delayed-start trial, treatment with levodopa/carbidopa had no disease-modifying effect over the course of 80 weeks in patients with early PD [1,2]. In patients without overt disability in daily activities, early start with levodopa improved disease-related quality of life. These were the results of a Dutch multicentre study designed to see if levodopa/carbidopa can slow disease progression in the early phase of the disease. A total of 445 patients with early PD were randomised to levodopa/carbidopa 100/25 mg three times a day for 80 weeks (early-start group), or placebo for 40 weeks followed by levodopa/carbidopa for 40 weeks (delayed-start group). The primary outcome was the mean change in the total score on the Unified Parkinson’s Disease Rating Scale (UPDRS) at week 80. This change w...

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