Prof. Wojciech Jurczak (Jagiellonian University, Poland) presented the history of trials in high-risk relapsed/refractory follicular lymphoma (FL), focussing on a pre-planned interim analysis of a recent phase 1b/2 study [1,2].
This open-label, single-arm trial assessed the safety and preliminary efficacy of polatuzumab vedotin in combination with obinutuzumab and lenalidomide (Pola-G-Len) in patients with relapsed/refractory FL (n=52). Polatuzumab vedotin is a first-in-class antibody-drug conjugate that targets CD76b, a protein expressed in FL and diffuse large B cell lymphoma (DLBCL). Polatuzumab vedotin in combination with rituximab and bendamustine was recently approved for the treatment of relapsed or refractory DLBCL.
The primary efficacy endpoint of the trial was complete response (CR) at the end of induction treatment, as assessed by an independent review committee based on PET-CT scans. Patients received Pola-G-Len induction treatment (six 28-day cycles). At a median follow-up of 16.6 months (range 3.2-25.1), the median progression-free survival (PFS) had not been reached, with a 12-month PFS rate of 90%. Two out of 17 responders have experienced progressive disease; the remaining patients have ongoing responses (longest one > 21 months).
No new safety signals were recorded, overall safety was comparable with previous reports in DLBCL. A grade 3 or higher neutropenia was reported in 30% of patients; 18% were febrile, and 9% had thrombocytopenia. Treatment was discontinued by 11% of patients due to AEs after receiving 1–5 cycles, and 8% of patients had a pola dose reduction. The results of this phase 1b-2 trial indicate Pola-G-Len treatment has a manageable toxicity profile and leads to promising response outcomes in relapsed/refractory follicular lymphoma.
- Jurczak W. 24th Congress of the EHA, 13-16 June 2019, Amsterdam, the Netherlands.
- Diefenbach, C. et al. Abstract 7505, 2019 ASCO Annual Meeting, Chicago, Illinois, USA.
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Table of Contents: EHA 2019
Interview with EHA President Prof. Pieter Sonneveld
Residual disease in AML patients prior to stem cell transplant increases relapse risk
Gilteritinib prolongs overall survival in patients with FLT3-mutated relapsed/refractory AML
Initial data on AMV564 in patients with relapsed/refractory AML
Overcoming the “don’t eat me” signal in AML and MDS
Asciminib plus imatinib in patients with heavily pre-treated chronic myeloid leukaemia
Guadecitabine vs treatment of choice in AML
Unmutated IGHV as predictive factor for venetoclax/obinutuzumab benefit in frontline CLL
CAR-T cell therapy in ALL as breakthrough advance
Brentuximab vedotin continues to demonstrate superior clinical activity in classical Hodgkin lymphoma
Infectious complications mild and not common in patients receiving CAR-T therapy for diffuse large B cell lymphoma
Obinutuzumab/polatuzumab in follicular lymphoma
Exciting survival data for ibrutinib vs placebo in treatment-naïve, early-stage CLL
ASCEND study: Acalabrutinib improves progression-free survival in relapsed/refractory CLL
Venetoclax-obinutuzumab combination elicits high response rates in CLL
CASSIOPEIA trial: Phase 3 results of daratumumab + bortezomib/thalidomide/dexamethasone in multiple myeloma
Chimeric antigen receptor T cell therapy in multiple myeloma
Higher levels of treatment satisfaction without compromising efficacy: subcutaneous daratumumab in RRMM
Adding isatuximab to pomalidomide and dexamethasone improves PFS and ORR in RRMM
Subcutaneous daratumumab + cyclophosphamide, bortezomib, and dexamethasone in patients with newly diagnosed amyloid light chain amyloidosis
Venetoclax for multiple myeloma: effective but some safety concerns
New sickle cell drug voxelotor boosts levels of haemoglobin
Positive initial data evaluating the safety and efficacy of IMR-687 for treatment of sickle cell disease
Haematopoietic stem cell transplantation improves stroke risk in children with sickle cell anaemia
Early trial data shows positive results for treating anaemia in patients with end-stage renal failure
Transformation of foetal haematopoietic stem and progenitor cells in the background of trisomy 21
Treating thalassemia twice, in mice
Haematopoietic stem cells can sense tissue damage in the gut
Promising news for gene therapy for sickle cell disease
Treating thalassemia twice, in mice