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First DLL3-targeted therapy shows promise in SCLC

Presented By
Prof. Hossein Borghaei, Fox Chase Cancer Center, PA, USA
WCLC 2022
Phase 1
Tarlatamab, the first delta-like ligand 3 (DLL3)-targeted immune therapy, demonstrated encouraging anti-tumour activity and an acceptable safety profile in patients with heavily pre-treated small cell lung cancer (SCLC). The results of the current phase 1 trial initiated the development of the phase 2 DeLLphi-301 study, analysing tarlatamab in patients with SCLC who received at least 2 prior lines of therapy [1]. “The treatment options for patients with pre-treated SCLC are limited,” stated Prof. Hossein Borghaei (Fox Chase Cancer Center, PA, USA). “Therefore, novel therapies are urgently needed for these patients.” Tarlatamab is a bispecific T cell-engager immune therapy that binds both DLL3 and CD3 [2]. The first-in-human study of tarlatamab evaluated this agent in 106 patients with SCLC who progressed on at least 1 platinum-based chemotherapy regimen. Safety was the primary outcome of this trial, in which patients received tarlatamab doses of up to 100 ...

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