Talazoparib plus temozolomide appears efficacious in ES-SCLC

The combination of talazoparib plus temozolomide reached the primary efficacy endpoint in a phase 2 study that tested this combination therapy in patients with extensive-stage small cell lung cancer (ES-SCLC). Since the safety profile was manageable, a phase 3 study is appropriate to confirm the clinical benefits of this treatment [1]. The current phase 2 trial (NCT03672773) evaluated the efficacy of the PARP inhibitor talazoparib in combination with temozolomide in 28 patients with relapsed or refractory ES-SCLC. Dr Jonathan Goldman (David Geffen School of Medicine at UCLA, CA, USA) presented the findings. An objective response rate (ORR) of 29% was needed to meet the primary endpoint. The ORR was 39.3%, representing 11 patients with partial responses. The median time to response was 1.8 months, and the median duration of response was 4.3 months. In additio...

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Posted on 23 August, 202223 August, 2022