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Defining phenotypes of MS-related cognitive impairment

Presented By
Dr Ermelinda De Meo, Vita-Salute San Raffaele University, Italy
ECF 2020
In a large and heterogeneous cohort of multiple sclerosis (MS) patients from Italy, 5 homogenous and clinically meaningful phenotypes of MS-related cognitive impairment were defined. These results can pave the way to future research on neuroanatomical substrates and help define tailored management strategies. Cognitive impairment is a common and disabling feature of MS, affecting 40-70% of patients. Altering the behaviour and quality of life of MS patients, it can lead to social and personal difficulties, sometimes despite minimal concurrent physical disability. Information processing speed and episodic memory are the cognitive functions most frequently affected in MS, but additional difficulties in executive function, verbal fluency, and visuospatial abilities have been reported. MRI has proven to represent a powerful tool in investigating the neuroanatomy of cognitive impairment in MS patients, but a precise characterisation of cognitive phenotypes is s...

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