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Decreased EDSS after plasma exchange in NMOSD

Presented By
Dr Enrique Gómez-Figueroa, National Institute of Neurology and Neurosurgery, Mexico
Conference
ECF 2020
In a large cohort of patients with relapsing neuromyelitis optica spectrum disorders (NMOSD), treatment with steroids and plasma exchange was accompanied by a significant decrease in Expanded Disability Status Scale (EDSS). The benefit of plasma exchange correlated with the number of cycles received and was independent of the underlying clinical syndrome. NMOSD are a group of inflammatory disorders of the CNS characterised by episodes of humoral-mediated inflammation. In concordance with the humoral pathogenesis, plasma exchange has proven to be a beneficial therapy in patients with severe NMOSD attacks [1]. The mechanism of action of plasma exchange involves the removal of different molecules that contribute to relapses of NMOSD, such as autoantibodies, complement proteins, and immune complexes. In an observational, retrospective study presented by Dr Enrique Gómez-Figueroa (National Institute of Neurology and Neurosurgery, Mexico), all NMOSD patie...


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