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UPDATE 1-Cannabidiol found to reduce drug-resistant seizures in tuberous sclerosis complex

Journal
JAMA Neurology
Reuters Health - 21/12/2020 - A phase-3 study treating people with drug-resistant tuberous sclerosis complex (TSC) seizures has concluded that cannabidiol can cut the seizure rate by as much as 30%. Compared with placebo, which was tied to a 26.5% reduction in seizure rate, an oral dose of 25 mg/kg/day of cannabidiol lowered the rate by 48.6% and a dose twice as large produced a 47.5% reduction, but with more side effects. In fact, "half of the patients randomized to 50 mg/kg/day (were) unable to reach or maintain that dosage" because of side effects, the researchers said. "I think CBD is a very important addition to our treatment options for patients with TSC, as 85% of individuals develop epilepsy, which is refractory to medication in about two thirds (compared to one third in the general epilepsy population)," chief author Dr. Elizabeth Thiele of Massachusetts General Hospital in Boston told Reuters Health in an email. The drug is already approved a...


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