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Plecanatide effective for IBS with constipation

Presented By
Prof. Eamonn M. Quigley, Houston Methodist Hospital, TX, USA
UEGW 2020
  The uroguanylin analogue plecanatide is an effective symptomatic treatment for patients with irritable bowel syndrome with constipation (IBS-C) [1]. An early clinical response to plecanatide appeared to be predictive of overall response after a treatment duration of 12 weeks. Plecanatide is indicated for the treatment of adults with IBS-C or chronic idiopathic constipation. In two phase 3 trials (NCT02387359 and NCT02493452), the efficacy and safety of plecanatide were demonstrated in patients with IBS-C. The current pooled analysis of these trials evaluated whether the treatment response during week 2 or 4 was predictive of overall treatment response after 12 weeks in 2,176 patients with IBS-C. At baseline, complete sponta...

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