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Dupilumab improves in diverse aspects of eosinophilic oesophagitis

Presented By
Prof. Evan S. Dellon, University of North Carolina School of Medicine, USA
UEGW 2020
Phase 3
  Weekly dupilumab demonstrated significant and clinically meaningful improvements in histologic, symptomatic, endoscopic, and molecular aspects of eosinophilic oesophagitis (EoE). In addition, dupilumab was well tolerated. That was found in part A of an ongoing 3-part, randomised, placebo-controlled, phase 3 study [1]. EoE is a chronic type 2 inflammatory disease of the oesophagus that can substantially impair the quality of life. Only a few treatment options are currently available and the response to the current therapy is generally suboptimal. Dupilumab, a fully human monoclonal antibody, blocks the shared receptor component for interleukin (IL)-4 and IL-13. These cytokines are key drivers of type 2 inflammation in EoE. In a previous phase 2 proof-of-concept study, dupilumab significantly improved histological and clinical ...

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