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Filgotinib effective as maintenance treatment for ulcerative colitis

Presented By
Prof. L Peyrin-Biroulet, Nancy University Hospital, France
Conference
UEGW 2020
Trial
Phase 3, SELECTION
The phase 2b/3 SELECTION study found that the JAK1 inhibitor filgotinib was effective and well tolerated as maintenance treatment for patients with moderately- to severely-active ulcerative colitis who had achieved clinical response to induction treatment with this drug [1]. Filgotinib is being investigated for several inflammatory conditions, including ulcerative colitis. The SELECTION maintenance study evaluated maintenance treatment with filgotinib in 664 patients with moderately- to severely-active ulcerative colitis who achieved clinical remission or Mayo Clinic Score (MCS) response after 10 weeks of induction with filgotinib 100 mg or 200 mg or placebo. Approximately 40% of patients were biologic-experienced. Patients randomised to filgotinib induction were re-randomised to their induction filgotinib dose or placebo. Patients randomised to placebo...


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