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Low-FODMAPs diet does not improve PPI-refractory GERD

Principal Investigator
Prof. Frank Zerbib, CHU de Bordeaux, France
UEGW 2020
An open-label study from France showed that a low-FODMAPs (Fermentable Oligo-, Di-, Mono-saccharides and Polyols) diet did not have any benefit over a standard diet to improve symptoms in patients with proton pump inhibitors (PPI)-refractory gastro-oesophageal reflux disease (GERD). Dietary advice is often proposed for patients with GERD. Previous studies demonstrated that a low-FODMAPs diet improved lower gastrointestinal symptoms. Colonic fermentation of alimentary carbohydrates has been shown to impact gastric and oesophageal motility and the occurrence of reflux episodes. The current multicentre, randomised, open-label study from France compared the efficacy of a 4-week low-FODMAPs diet with a standard diet in 31 patients (55% female, median age 45 years) with symptomatic PPI-refractory GERD, defined by a Reflux Disease Questionnaire (RDQ) score >3 and abnormal pH-impedance monitoring on PPIs [1]. Adherence to the assigned diet was goo...

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