Stimulation of PD-1: a new concept to treat RA

Peresolimab was significantly superior to placebo in reducing the Disease Activity Score-28 with C-reactive protein (DAS28-CRP) as well as Clinical Disease Activity Index (CDAI) in patients with rheumatoid arthritis (RA). The safety profile did not demonstrate a dose effect of the study drug. The programmed cell death protein 1 (PD-1) agonist peresolimab represents a novel mode of action for the therapy of RA. “We hypothesised that peresolimab binding to PD-1, which is a checkpoint inhibitory receptor, could stimulate physiological immune pathways and restore immune homeostasis,” Prof. Paul Emery (University of Leeds, UK) informed [1]. The presented phase 2a trial (NCT04634253) enrolled participants with moderate-to-severe active RA who had a prior failure to not more than 2 conventional synthetic, biologic, or targeted synthetic DMARDs. In this study, 98 pa...

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Posted on 1 December, 20221 December, 2022