The ACR Convergence 2021 was originally scheduled to take place at the Moscone Center in San Francisco, but decided to go 100% virtual because of the ongoing Coronavirus pandemic. Given the time of year, the famous city and the Southern Californian climate, it would be hard to generate virtual memories that could come anywhere near the experience of once boots on the ground in San Francisco.
That being said, the ACR in its own words attempted to deliver âgroundbreaking science, innovative formats, live programming, networking, and flexible schedulingâ and succeeded in doing so. With over 14,000 rheumatology professionals from >110 countries registering to hear over 300 speakers and over 2,000 abstracts, there was something for everyone.
Herein, we have briefly highlighted novel and interesting research across the breadth of the Rheumatic Diseases. Naturally, we have highlighted abstracts pertaining to COVID-19 from the rheumatology perspective and, reassuringly, the positive data that Rheumatology patients were mostly faring well during the pandemic continues to be the case nearly a year after the generation of the original data that was presented at the ACR in November 2021. One of our core activities involves the use of immunosuppression of B- and T-cell activity in the battle to restore immune homeostasis and unsurprisingly this can sometimes manifest as worse COVID-19 disease or inferior vaccination responses, and selected abstracts deal with this topic.
Moving from San Francisco to a famous New York Yankee quote, we also had a Rheumatological âdĂ©jĂ vu all over againâ moment with evidence that very low dose rituximab, analogous to very low dose methotrexate, made the successful jump from cancer to rheumatoid arthritis. Lets hope that by the end of 2022 we can simply say that it is âall overâ and we can return to meeting our colleagues face-to-face at the ACR.
Kind regards,
Prof. Dennis McGonagle
Biography:
Dennis McGonagle, FRCPI, PhD, is an Academic Rheumatologist at the University of Leeds and section head of Experimental Rheumatology. He graduated in Medicine from the University College Dublin in 1990 and undertook postgraduate training in Dublin and Leeds where he completed his PhD. He has developed the modern enthesitis model for spondyloarthropathies and psoriatic arthritis including the cytokine-mediated enthesis originating theory of disease (Lancet 1998). He also described the synovioentheseal complex, nail anchorage to the skeleton, developed an integrated biomechanical and immunology model for PsA, and a mechanistic disease classification of immune diseases (PLoS Med 2006). His group also discovered synovial fluid mesenchymal stem cells, which is being researched towards osteoarthritis therapy development. Prof. McGonagle has also served on the EULAR scientific committee and is a member of the Editorial Board of ARD.
Conflict of Interest Statement:Â Â Prof. McGonagle has undertaken research and/or educational programme activities with Pfizer, MSD, AbbVie, BMS, UCB, Novartis, Celgene, and J&J.
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Table of Contents: ACR 2021
Featured articles
Late-Breaking Abstracts
Vaccine booster improves immune response in patients treated with rituximab
IL-17 inhibition showing efficacy in GCA in phase 2 trials
Spotlight on Rheumatoid Arthritis
Cycling JAK inhibitors shows similar effectiveness to switching to a bDMARD in difficult-to-treat RA
Pre-existing heart failure affects safety of hydroxychloroquine in RA patients
Patients with RA-associated interstitial lung disease benefit from antifibrotic agent
Ultra-low dosing of rituximab in RA is a viable treatment option
Kidney disease and hydroxychloroquine dose are risk factors for developing retinopathy
More pros than cons for the use of statins in RA
Psoriatic Arthritis: Novel Developments
Selective IL-23 inhibition: a new option in active PsA
Ustekinumab: highly efficacious in PSA independent of methotrexate
COVID-19: What You Need to Know
Vaccinated rheumatic patients carry increased risk for COVID-19 breakthrough infections
B-cell depleting medication increases COVID-19 breakthrough infection outcome risk
COVID-19 mRNA vaccine safe and tolerable in adults with autoimmune disease
SLE Treatment: What Is New
Iberdomide: an upcoming new treatment possibility in lupus erythematosus
Sequential rituximab after belimumab does not improve disease control in SLE
Lupus patients less protected by COVID-19 vaccine
Late-Breaking Posters
Promising results in uric acid-lowering in gout patients with a new xanthine oxidase inhibitor
Laboratory and clinical signs 24h after hospitalisation predict MIS-C in children
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