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Mutational analyses are predictive in malignant lymphomas

Presented By
Dr Ismael Fernández-Miranda, Institute of Sanitary Investigation Puerta de Hierro, Spain & Dr Shan-Shan Li, Hospital of Sun Yat-sen University, China
Conference
ESMO 2021
Mutational profiles are predictive for transformation in patients with follicular lymphoma and for overall survival in patients with gastrointestinal diffuse large B-cell lymphoma (DLBCL), 2 presentations showed. Follicular lymphoma is an indolent but mainly incurable disease. Histological transformation to DLBCL is associated with rapid progression, treatment resistance, and poor prognosis. Prior research showed a prognostic signature for transformation [1]. Dr Ismael Fernández-Miranda (Institute of Sanitary Investigation Puerta de Hierro, Spain) now reported on the validation of a previously identified, prognostic, genetic signature (DTX1, HIST1H1E, UBE2A, NOTCH2) [2]. A targeted massive parallel sequencing was performed on new diagnostic samples from 21 pre-transformed and 30 non-transformed patients. Additionally, the previously published cohort of 42 samples (22 pre-transformed and 20 non-transformed patients) was included to enable r...


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