I have again the privilege to present to you our congress report from ESMO 2021 Annual, this time from Paris. We’ll wrap up major results even better than Christo’s wrapping of the Arc de Triomphe (which took place at the same time). Thanks to COVID-19 this was again a largely virtual event, as audiences on-site mainly consisted of (other) speakers.
A lot to read through? Yes, it is! That’s because this congress was again loaded with practice-changing and other relevant studies:
We knew it, studies confirm it:
Cancer patients better get their jab, and better not get into the hospital (due to serious COVID-19 infection).
Chemotherapy is back!
- In form of conjugates: more precise, more lethal (to cancer cells, that is), and less toxic (to their hosts). Here’s brand new standards in breast and non-small cell lung cancer. Expect more to come.
- “Vintage chemo” also has a revival: nearly buried by many of us, MVAC made it to the headlines as neoadjuvant standard in early bladder cancer with a relevant survival benefit.
- And upfront chemo may be back in metastatic prostate cancer: The whole works with double hormone blockage AND docetaxel shows highly superior results as compared to less intensive approaches in the PEACE trial.
There’s a potent weapon coming up for KRAS mutant mCRC, we might get closer to get “cold” MMS colorectal cancer to warm up to immunotherapy, and there are very interesting less toxic schedules to administer TKI’s and check-point inhibitors in urothelial cancers…
We take pride in providing you with these and many more important news in professional, peer-reviewed articles. I’m sure you will enjoy our report.
Yours, sincerely
Stefan Rauh
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Table of Contents: ESMO 2021
Featured articles
Breast Cancer
Trastuzumab deruxtecan triples PFS
Novel conjugate meets primary endpoint
Longest survival benefit from first-line CDK4/6 inhibitor
Meta-analysis shows 6-months adjuvant trastuzumab is optimal
Double-positive results for triple-negative metastatic breast cancer
Survival after neoadjuvant therapy with trastuzumab-lapatinib plus chemotherapy
Postmenopausal breast cancer: extended letrozole reduces recurrence
Asian women also benefit from palbociclib plus letrozole
No PEARLs of survival with palbociclib plus endocrine therapy compared with capecitabine, but QoL better
Gastrointestinal Cancer
Neoadjuvant chemotherapy potential alternative to neoadjuvant chemoradiotherapy in LARC
Immune chemo-sensitisation looks promising in microsatellite-stable mCRC
Adagrasib shows promising clinical activity in heavily pretreated KRAS-mutated CRC
Automated detection of microsatellite status on unstained samples in early colon cancer
Consistent benefit of anti-PD-1 therapy for oesophageal and gastric cancer
HIPEC in gastric cancer with peritoneal metastases
ctDNA highly predictive in HER2-positive, advanced gastric or gastro-oesophageal junction cancer
Lung Cancer
Robust anticancer activity of trastuzumab deruxtecan in HER2-mutated NSCLC
Nivolumab/ipilimumab continues to provide survival benefit in unresectable MPM
Adjuvant atezolizumab lowers relapse rate in resected NSCLC
Three-year OS follow-up from CASPIAN trial
TCR clonality predicts pembrolizumab response in NSCLC
Melanoma
Adjuvant immunotherapy reduces risk of disease recurrence in stage II melanoma
IFN-γ signature predicts response to immunotherapy
Updated results of SECOMBIT trial
Combining T-VEC and pembrolizumab does not significantly improve survival in advanced, unresectable melanoma
Durable intracranial responses with nivolumab/ipilimumab
Genitourinary Cancer
TKI drug-free interval strategy not detrimental to conventional continuation strategy in RCC
Modified ipilimumab schedule reduces risk of grade 3/4 adverse events
Optimal neoadjuvant dose ipilimumab/nivolumab in stage III urothelial cancer
Better survival with neoadjuvant dose-dense MVAC regimen in MIBC
PARP inhibitor rechallenge improves PFS in ovarian cancer
Pembrolizumab prolongs survival in persistent, recurrent, or metastatic cervical cancer
Pembrolizumab has durable effect in previously treated MSI-H/dMMR advanced endometrial cancer
HRR mutational status is prognostic and predictive biomarker olaparib activity
Haematological Cancer
Mutational analyses are predictive in malignant lymphomas
Low numbers of M2 macrophages in tumour microenvironment associated with superior response to immunotherapy in Hodgkin lymphoma
COVID-19
Adequate response to SARS-CoV-2 vaccine in cancer patients
Cancer patients more likely to die from COVID-19 when hospital admittance is required
Third global survey of the ESMO Resilience Task Force
High COVID-19 mortality in Swiss cancer patients
Basic Science & Translational Research
Neutrophils negatively correlate with response to anti-PD-1 monotherapy in dMMR tumours
Tetraspecific ANKETs harnesses innate immunity in cancer therapies
Early ctDNA reduction in metastatic uveal melanoma correlates better with OS than RECIST response
Gut microbiota as a potential predictive biomarker
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