Dear Reader,
It is my pleasure to introduce this peer-reviewed ASH 2020 Medicom Conference Report. Although it was a virtual meeting due to the COVID-19 pandemic, many interesting presentations could be followed via the screen. We were able to select a number of interesting abstracts that probably will change your practice, but also more basic items are included in this summary. The presentations are summarised in a way that the information is easy to digest in a rather short time.
This year we saw a further increase in the number of new drugs under development in a variety of haematological disorders. We also selected some abstracts devoted to the COVID-19 pandemic and the implications for your daily practice. As in the previous ASH meetings, the number of abstracts on immunotherapy including bispecific antibody and CAR T-cell treatment applied in a variety of haematological malignancies was rising. Treatment of AML, a disease in which for a long time we had to rely on very few innovations, is rapidly changing with the development of new effective targeted treatments especially in the patients who are not fit for intensive treatment. But also in the other haematological disorders new treatments were discussed. You will find snapshots of all these new developments in this report. I am sure you will enjoy.
Gert Ossenkoppele
Biography
Professor Gert Ossenkoppele was appointed in 2003 as professor of Haematology at the VU University Medical Center in Amsterdam, now named Amsterdam UMC, location VUMC. Gert Ossenkoppele has authored over 420 publications in peer-reviewed journals and is an invited speaker at many international scientific meetings. His research interests are mainly translational and include the (stem cell) biology of AML, leukemic stem cell target discovery, immunotherapy, and measurable residual disease (MRD) detection using flow cytometry to inform treatment of AML. He is the PI of various clinical trials in myeloid malignancies. He chairs the AML working party of HOVON (Dutch-Belgian Haematology Trial Group) He is a lead participant of the AML Work package of the European LeukemiaNet (ELN) as well as a board member of the ELN foundation. He is appointed as chair of the EHA Educational Committee. He just stepped down as chair of the AML Scientific working group of EHA, and he is chair of the Global and EU steering committee of the AMLGlobalPortal, an educational portal for haematologists (www.amlglobalportal.com).
Conflicts of interest
Professor Gert Ossenkoppele is a member of research support for Novartis, J&J and BMS-Celgene.
He functions as a consultant for J&J, Daiichi-Sanyko, BMS-Celgene, Servier, and Roche. Lastly, he is a member of the advisory boards of Novartis, Pfizer, Abbvie, J&J, Daiichi-Sanyko, BMS-Celgene, AGIOS, Amgen, Astellas, Roche, Jazz pharmaceuticals, and Merus.
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Table of Contents: ASH 2020
Featured articles
COVID-19
More complicated course of COVID-19 in leukaemia patients
Older age and imatinib treatment associated with COVID-19 mortality in CML
Allogeneic SARS-CoV-2-specific T cells to treat COVID-19
More severe COVID-19 outcomes for patients with haematologic malignancies
Acute Lymphoblastic Leukaemia
Improved outcomes, but still substantial part experiences relapses
Strong correlation between peripheral blood and bone marrow NGS MRD
Encouraging outcomes after autoHCT in patients with ALL
Acute Myeloid Leukaemia
Prognostic validity of AML composite model in predicting mortality
Venetoclax plus hypomethylating agents in favourable-risk AML
Encouraging clinical activity of decitabine plus ipilimumab in R/R or secondary MDS/AML
AML patients with specific mutations are unlikely to achieve MRD
Comparable outcomes with gilteritinib or quizartinib in R/R AML
First-in-class macrophage immune checkpoint inhibitor in AML
Bispecific DART® as salvage therapy for primary induction failure and early relapse
Gilteritinib in R/R AML patients priorly treated with midostaurin or sorafenib
Addition of venetoclax provides an effective, lower-intensity regimen
Chronic Leukaemia
Bosutinib effective and well tolerated in newly diagnosed CP-CML
Efficacy and safety of ponatinib in patients with CP-CML who failed second-generation TKIs
First-in-class STAMP inhibitor versus bosutinib in resistant or intolerant CML
PFS and ORR benefits of first-line ibrutinib-based treatment in CLL
Multiple Myeloma
Validation of MY-RADS response assessment category criteria
High symptom burden in transplant-ineligible patients with newly diagnosed MM
Added value of ixazomib to lenalidomide plus dexamethasone in transplant-ineligible newly diagnosed MM
Survival of transplant-eligible newly diagnosed MM in FORTE trial
Better survival with upfront autoSCT versus bortezomib-based intensification
Subcutaneous daratumumab plus pomalidomide and dexamethasone in R/R MM
Melflufen well tolerated with encouraging activity in heavily pretreated R/R MM
Initial data of FcRH5/CD3 T-cell-engaging bispecific antibody
Lymphoma
CD58 aberrations limit durable responses to CD19 CAR T-cell therapy
Anti-CD19 CAR T-cell therapy in relapsed/refractory indolent NHL
Myeloproliferative Neoplasms
MPN disease burden, quality of life, and treatment patterns
Interventions in JAK/STAT signalling pathway
Novel, orally available inhibitor of BCL-XL/BCL-2
New insights into genetics of MPN
Immune Thrombocytopenia
Mycophenolate efficacious and tolerable, even in elderly patients
First-in-class antibody sutimlimab selectively inhibits classical complement pathway
BTK inhibition provides clinically active and durable platelet response
Haemophilia, Sickle Cell Disease, Thalassaemia
First results from gene therapy trial in haemophilia B
Impact of haemophilia on children and their caregivers
Promising CRISPR gene editing results in β-thalassaemia and sickle cell disease
Erythroid maturation agent in patients with β-thalassaemia requiring regular RBC transfusions
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