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Polygenic score predicts sudden death in CAD

Dr Roopinder Sandu, Smidt Heart Institute, CA, USA
Journal of the American College of Cardiology
In patients with coronary artery disease (CAD) without severe left ventricular dysfunction from the prospective cohort study named PRE-DETERMINE (NCT01114269), a validated genome-wide polygenic risk score was predictive of sudden cardiac death (SCD) [1]. The polygenic score may possibly improve the risk stratification for patients with CAD who are not eligible for implantable cardioverter-defibrillators (ICDs) according to the current guidelines. According to Dr Roopinder Sandu (Smidt Heart Institute, CA, USA) and co-investigators, the options for predicting SCD in patients with CAD and an ejection fraction above 35% are limited, notwithstanding that SCD frequently occurs in this population. Therefore, the research team analysed genome-wide genotyping of 4,698 patients who were enrolled in the PRE-DETERMINE study to develop a genom...

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