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ES-SCLC: tremelimumab + durvalumab + chemotherapy misses endpoint

Presented By
Prof. Luis G. Paz-Ares, Hospital 12 de Octubre, Spain
ASCO 2020
Phase 3, CASPIAN
Featured video: Durvalumab ± tremelimumab + platinum-etoposide in first-line extensive-stage SCLC (ES-SCLC): Updated Results from the phase III CASPIAN study. https://vimeo.com/440629763 The addition of tremelimumab to frontline durvalumab and platinum-based chemotherapy did not demonstrate a statistically significant improvement in overall survival (OS) in patients with extensive-stage small cell lung cancer (ES-SCLC), missing the co-primary endpoint of the phase 3 CASPIAN study. Presented by Prof. Luis Paz-Ares (Hospital 12 de Octubre, Madrid, Spain), this was the first report of the third study arm of CASPIAN, in which the investigational CTLA-4 inhibitor tremelimumab was added to PD-L1 checkpoint inhibitor durvalumab on top of standard of care chemotherapy [1]. ...

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