Oral JAK 1 inhibitor leads to fast itch relieve and remarkable skin clearance in AD

Oral administration of the JAK1 inhibitor upadacitinib given as monotherapy showed a remarkable efficacy and speed of response in patients with moderate-to-severe atopic dermatitis (AD) in 2 replicate, multicentre, phase 3 trials. The Janus kinase (JAK) inhibitor upadacitinib was specifically developed for therapy of AD as key cytokines involved in the pathogenesis of AD signal via the JAK1 pathway. A previous phase 2b trial demonstrated that upadacitinib monotherapy was efficacious with a favourable benefit-risk profile compared with placebo in adults with moderate-to-severe AD. The 2 replicate, randomized, double-blind, phase 3 trials Measure Up 1 and Measure Up 2 aimed to evaluate the efficacy and safety of monotherapy with upadacitinib versus placebo in adolescents and adults with moderate-to-severe AD. Prof. Emma Guttman-Y...

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Posted on 3 November, 202018 December, 2020