Real-world data on brodalumab affirm efficacy and fast onset of action

A German study investigated the performance of brodalumab for the treatment of psoriasis in real-world conditions. They found meaningful responses as of week 2 and the highest clearance rates in biologic-naïve patients.

In clinical phase 3 trials, brodalumab was shown to have remarkable efficacy and early commencing action in psoriasis patients. The authors aim to assess this translates into a patient population encountered in daily practice [1]. The ongoing, prospective, non-interventional study investigates the real-world evidence of brodalumab in disease management of psoriasis after 12 and 52 weeks. Data was obtained between November 2017 and January 2020 from 216 German study centres on the effect of brodalumab on the absolute psoriasis area severity index (aPASI) of over 500 patients. Dr Ralph Von Kiedrowski (Germany) presented the 12-week results of the study at the EADV Congress.

Mean age of study subjects was 50, mean duration of disease 20 years, and 64.9% of the patients were male. Baseline grades of psoriasis severity were 28% mild, 41% moderate, 19% severe, and 12% very severe. More than half of the patients had never received biologics before (57.2%). Of those who received preceding biological therapy, 39% were changed within 3 months from IL-17A antagonists, 47% from TNF-blockers, and 17% from IL-23/12 or IL-23 antagonists.

At week 12, 77.2% of the patients met the primary endpoint of an aPASI ≤3. Interestingly, the mean aPASI already dropped from 16.9 at baseline to 9.1 by week 2 and continued to decrease to 4.8 at week 4. PASI75 and PASI100 were achieved by 82.3% and 37.0% of the biologic-naïve patients compared with 64.8% and 27.8% with previous TNF-blocker treatment, respectively.  After 12 weeks, complete clearance (PASI100) was reached by one-quarter of the patients in the baseline category of very severe psoriasis (mean PASI 30.5).

In conclusion, this large study on real-word evidence confirms that brodalumab induces swift ameliorations of aPASI with a high grade of efficacy.

 

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   1. Von Kiedrowski R, et al. Management of moderate-to-severe psoriasis with brodalumab in daily practice conditions - first real-world-evidence (RWE) results from the LIBERO trial. P1307, EADV Virtual, 29-31 October 2020.

 



Posted on 30 October, 202018 December, 2020