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Antifibrotic therapy may slow down FVC decline in RAILD

Presented By
Prof. Ivan Rosas, Baylor College of Medicine, TX, USA
ERS 2022
Phase 2, TRAIL1
A phase 2 study examining pirfenidone in patients with rheumatoid arthritis associated interstitial lung disease (RAILD) did not meet its primary endpoint. Nonetheless, a trend was observed towards a beneficial effect for the agent under investigation, especially for patients with RAILD who displayed a pattern of usual interstitial pneumonia (UIP) on CT imaging. Rheumatoid arthritis (RA) is the most common connective tissue disease, with a prevalence of 0.75% in the USA [1]. In addition, interstitial lung disease (ILD) occurs in 19–63% of the patients with RA [1]. To target RAILD, Prof. Ivan Rosas (Baylor College of Medicine, TX, USA) and colleagues designed the phase 2 TRAIL1 study (NCT02808871), in which 123 patients with RAILD were randomised to the antifibrotic agent pirfenidone or placebo [2]. The primary endpoint was a decline in percent predicted FVC by 10% ...

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