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TGF-beta signaling impairs T cell-mediated cancer immunity

Reuters Health - 22/10/2020 - Transforming growth factor (TGF)-beta impairs the ability of CD4+ T cells to prevent cancer progression, but blocking TGF-beta signaling in these cells restores their ability to remodel the tumor microenvironment and trigger cancer-cell death, researchers report. "We were most surprised to find that the immune system can effectively repress cancer progression by targeting the cancer environment rather than the cancer cell itself," Dr. Ming O. Li of Memorial Sloan Kettering Cancer Center and Weill Cornell Graduate School of Medical Sciences, in New York City, told Reuters Health by email. Blockage of TGF-beta signaling inhibits tumor development, but its functional target and underlying mechanism of cancer regulation remain unclear. Dr. Li and colleagues investigate the effects of TGF-beta on type-2 immunity to cancer and the impact of targeted TGF-beta-signaling blockade in T helper 2 (Th2) cells on the tumor microenvironment and...

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