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Immune factors linked to poor survival in Black breast cancer patients, immunotherapy potentially helpful

Reuters Health - 12/01/2021 - Black women with breast cancer exhibit an "exhausted" T-cell profile associated with poor survival, and may benefit from checkpoint inhibitor therapy targeting their unique phenotype, researchers suggest. "Until now, triple negative breast cancer has been the only breast cancer subtype commonly treated with immunotherapy," principal author Christine Ambrosone of Roswell Park Comprehensive Cancer Center in Buffalo, New York told Reuters Health by email. "Our findings that tumors from Black women have higher levels of exhausted immune cells indicate that, regardless of breast cancer subtype, immunotherapy may be effective in treating Black women with breast cancer." First author Dr. Song Yao, also of Roswell Park, added, "We have not studied directly what might be responsible for the exhausted immune phenotype, but one theory suggests that chronic inflammation and a robust immune response could contribute to this phenomenon. Because the o...


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