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Intestinal IgA-producing B cells help curb CNS inflammation in MS

Journal
Science Immunology
Reuters Health - 03/12/2020 - During a multiple sclerosis (MS) exacerbation, specific IgA-producing B cells in the intestines travel to inflamed sites in the central nervous system (CNS), exerting an anti-inflammatory effect, researchers say. Principal author Dr. Sergio Baranzini of the University of California, San Francisco told Reuters Health that his group's previous work "described an unprecedented phenomenon in which IgA-producing cells from the gut migrated to the brain to dampen inflammation in an experimental (murine) model of MS called EAE. (https://bit.ly/3olsjbF) Here we wanted to test whether this process was also at play in humans with MS." "We discovered that IgA-producing cells leave the gut and enter the CNS during an MS exacerbation. These cells produce IgA that can be found in the cerebrospinal fluid (CSF) and this could be a biomarker of neuroinflammation," he explained. "This IgA recognizes specific molecules present on the surface of certain gu...


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