Unfortunately, due to COVID-19 restrictions, ECCO (European Crohn’s and Colitis Organisation) 2022 was for the second time an online event.
The theme of this year was “Navigating the Oceans of IBD”, with tantalizing topics such as “Developing environment recipes for IBD”, “Keeping the patient at home: Is telemedicine the future?”, “Aiming high with treatment goals in IBD: The modern Icarus?” and ‘Do we see light at the end of the fistula track”.
Although COVID-19 has had a major impact on our daily lives, the quality of IBD research has not been affected. It is a great honour to present this ECCO 2022 Medicom Conference Report in which we cover amongst others updates on new therapies, head-to-head comparisons and insights into specific therapeutic strategies. I hope you enjoy it and am looking forward to meeting you in person next year in Copenhagen.
Yours, sincerely
Marjolijn Duijvestein
Biography
Dr Marjolijn Duijvestein works as a gastroenterologist in the IBD team of the Radboudumc in Nijmegen, the Netherlands. In 2012 she obtained her PhD at Leiden University and was trained as a gastroenterologist specialised in IBD disease at the Amsterdam UMC in Amsterdam. As part of her training, she gained experience at the University of California San Diego (UCSD, USA) and performed an internship at Alimentiv (former Robarts Clinical Trials), an academic research organisation dedicated to drug development for IBD. Her clinical activity and research are focused on IBD, in particular clinical and translational research.
Conflict of Interest Statement: She has served as an advisor for Echo pharma and Robarts Clinical Trials, reports nonfinancial support from Dr Falk Pharma, and received speaker fees from Janssen, Merck & Co., Pfizer, Takeda and Tillotts Pharma. Advisory boards Janssen, Takeda, BMS and Abbvie.
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Table of Contents: ECCO 2022
Featured articles
Upadacitinib maintenance therapy delivers sustained improvements in active ulcerative colitis
Novel Treatment Modalities
Guselkumab shows encouraging safety and efficacy in ulcerative colitis
Guselkumab maintenance therapy achieved high efficacy rates in Crohn’s disease
Mirikizumab efficacious for active ulcerative colitis
Risankizumab more efficacious in colonic than in ileal Crohn’s disease
Guselkumab plus golimumab promising combination for ulcerative colitis
Combined endpoint may support personalised medicine in ulcerative colitis
Filgotinib seems promising for perianal fistulising Crohn’s disease
Upadacitinib maintenance therapy delivers sustained improvements in active ulcerative colitis
Upadacitinib counters extraintestinal manifestations in ulcerative colitis
Deucravacitinib does not meet primary endpoint for ulcerative colitis
Head-to-Head Comparisons
Anti-TNFs versus vedolizumab and ustekinumab in Crohn’s disease
Upadacitinib appears to be an efficacious therapy for moderately-to-severely ulcerative colitis
Subcutaneous infliximab versus subcutaneous vedolizumab in IBD
Vedolizumab outperforms anti-TNF in biologic-naïve ulcerative colitis
Short-Term and Long-Term Treatment Results
Ozanimod treatment shows maintained response in ulcerative colitis
Stopping infliximab but not antimetabolites leads to more relapses in Crohn’s disease
Vedolizumab first approved therapy for chronic pouchitis
VEDOKIDS: Vedolizumab seems effective in paediatric IBD
Primary endpoint of 5-hydroxytryptophan for fatigue in IBD not met
Specific Therapeutic Strategies
Positive outcomes with therapeutic drug monitoring during infliximab maintenance therapy
Segmental colectomy beneficial over total colectomy in Chrohn’s disease
Modified 2-stage ileal pouch-anal anastomosis versus 3-stage alternative
Similar results for different corticosteroid tapering protocols in UC
Miscellaneous Topics
Lessons from the COVID-19 pandemic for IBD management
AI model distinguishes between histologic activity and remission in ulcerative colitis
Multi-Omic and dietary analysis of Crohn’s disease identifies pathogenetic factors
Novel classification system for perianal fistulising Crohn’s disease
Vaccination tool associated with improved vaccination coverage in IBD
Comparable safety profiles of biological therapies in elderly patients with IBD
Early biologic therapy induces larger effect than delayed treatment in Crohn’s disease
RESTORE-UC: No better outcomes with FMT superdonors than with autologous stools
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