An association between sleep disturbances and vitamin D deficiency, which may negatively influence the quality of life of patients with Crohn’s disease (CD), has been shown by an Irish study. Hence, checking vitamin D levels could be helpful in patients with CD suffering from poor sleep.
Patients with inflammatory bowel disease (IBD) commonly experience impaired sleep [1,2]. Factors associated with poor sleep include corticosteroid use, depression, and disease activity. Furthermore, IBD patients often have a low vitamin D level, which has been identified as a factor independently linked to a reduced quality of life .
To evaluate a possible correlation between poor sleep and the individual level of vitamin D in patients with CD, a team from Tallaght University in Ireland set up a study with 54 invited patients with CD, whose evaluation included vitamin D level testing and the assessment of their sleep quality.
The median age of the participants was 42.5 years, half of them were women, and 24% were found to have severe vitamin D deficiency. CD was diagnosed at a mean of 17 years prior. Nearly half of the participants were in remission (46%), as measured by the Harvey-Bradshaw index. Mild and moderate activity was present in 13% and 37% of the participants, respectively, while 4% had severe CD.
Sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI), with values >5 indicating poor sleep quality. This was true for 61% of the study cohort, which presented a mean PSQI of 7.7 overall. When comparing PSQI between participants with vitamin D values that indicated deficiency and those with normal vitamin D values, a significant difference was observed with a PSQI of 10.5 and 6.7 (P=0.008), respectively.
Based on these results, the authors concluded that poor sleep and vitamin D deficiency are linked, leading to a negative impact on the patient’s quality of life. These findings prompted Dr Caroline Walker (Tallaght University Hospital, Ireland) to encourage vitamin D testing in CD patients with fatigue and sleep disturbances.
- Ananthakrishnan AN, et al. Clin Gastroenterol Hepatol. 2013;11:965–71.
- Walker C, et al. Vitamin D deficiency is associated with poor sleep quality in patients with Crohn’s disease. P165, ECCO 2023, 01–04 March, Copenhagen, Denmark.
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Table of Contents: ECCO 2023
Letter from the Editor
ECCO 2023 Highlights Podcast
What Is New in Biologic Therapy?
Beneficial effect of early, post-operative vedolizumab on endoscopic recurrence in CD
Long-term data supports the established efficacy and safety of ustekinumab in UC
Anti-TNF withdrawal may be a safe option in stable IBD
Intensified drug therapy leads to better stricture morphology in CD
Small Molecules in IBD: State of the Art
Continued efficacy of long-term ozanimod as UC treatment
Upadacitinib successful in the management of both CD and UC
Solid results for long-term therapy of UC with filgotinib
Paediatric IBD: What You Need To Know
Perinatal period is crucial for the risk of developing CD
Early-life antibiotic exposure: a risk factor for paediatric-onset IBD
Paediatric patients with immune-mediated inflammatory disease harbour a heightened cancer risk
Risk Factors and Complications of IBD
Checking kidney function is important during the course of IBD
Diabetes therapy with GLP-1-based drugs does not elevate the risk of IBD
Surgical Approaches: New Developments
Long-term resection potentially better than anti-TNF treatment in CD
Early, post-operative complications in CD reduced by pre-operative enteral nutrition, irrespective of biologic exposure
Pearls of the Posters
Drop in overall IBD procedures during the pandemic
Proton pump inhibitors associated with worse outcomes in CD
Poor sleep in CD linked to low levels of vitamin D
Novel AI tool assessing mucosal inflammation achieves high correlation with histopathologists