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Cigarette smoke tied to colorectal neoplasia in IBD patients

Clinical Gastroenterology & Hepatology
Reuters Health - 29/01/2021 - While cigarette smoke exposure is associated with an increased risk of colorectal neoplasia in patients with inflammatory bowel disease (IBD), a new study suggests that the risk may differ for those with ulcerative colitis or Crohn's disease. Researchers examined data on 1,386 patients with IBD who had at least one pathology report from a colorectal biopsy and provided information on any cigarette exposure, including current and former active smoking as well as passive exposure. Overall, a total of 153 patients (11.5%) were diagnosed with colorectal neoplasia. Crohn's disease patients were more likely to develop colorectal neoplasia when they were current smokers (hazard ratio 2.20), as well as when they had current or childhood passive smoke exposure (HR 1.87 and 4.79, respectively). The trend for increased risk among former smokers (HR 2.16) wasn't statistically significant. Ulcerative colitis patients, however, had an increase...

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