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Study supports routine physiologic assessment to guide revascularization

Journal
JAMA
Reuters Health - 16/11/2020 - In patients with coronary-artery disease (CAD), having percutaneous coronary intervention (PCI) according to evidence-based fractional flow reserve (FFR) thresholds is associated with improved clinical outcomes compared to not having PCI, a large retrospective study shows. The study also suggests potential harm from performing PCI outside of FFR thresholds. Based on clinical-trial data, PCI is generally recommended for lesions with ischemic FFR values (FFR <=0.80) but not for lesions with nonischemic FFR values (FFR >0.80) because it has not been demonstrated to be beneficial and may be harmful, the study team explains in JAMA. "There has been a paucity of data in the real world to see whether FFR is used appropriately or whether what we see in the randomized trials are translated to practice," Dr. Dennis Ko of the University of Toronto and the Institute for Clinical Evaluative Sciences (ICES), in Canada, told Reuters Healt...


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