Calcium chloride during CABG curbs subsequent atrial fibrillation

Reuters Health - 18/01/2021 - Injecting calcium chloride (CaCl2) into the major atrial ganglionated plexi (GP) during isolated coronary-artery bypass grafting (CABG) appears to prompt a major reduction in atrial fibrillation (AF), according to a proof-of-concept randomized trial. "This readily available, inexpensive treatment may significantly reduce the incidence of postoperative atrial fibrillation and associated healthcare costs," Dr. Sunny S. Po of the University of Oklahoma Health Sciences Center, in Oklahoma City, told Reuters Health by email. Postoperative AF (POAF) is one of the most common complications of cardiac surgery, Dr. Po and colleagues note in The Journal of the American College of Cardiology. Suppression of the function of the atrial GPs (using botulinum toxin) they add, has been shown to reduce the incidence of POAF. In light of these and other findings, the researchers hypothesized that calcium-mediated neurotoxicity might be induced by i...

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Posted on 18 January, 202119 January, 2021