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Study shows no mortality increase if paclitaxel coats peripheral-artery devices

Journal
The New England Journal of Medicine
Reuters Health - 09/12/2020 - Analysis of data from a Swedish registry has failed to uncover any evidence that endovascular devices coated with paclitaxel increase mortality when used to treat symptomatic peripheral-artery disease (PAD). A 2018 meta-analysis published in the Journal of the American Heart Association had suggested a risk for angioplasty balloons and stents used for lower-limb endovascular interventions. The new assessment, in the New England Journal of Medicine, found a death rate of 25.5% after a mean of 2.5 years for 1,149 volunteers treated with paclitaxel-coated devices. The rate is virtually identical - 24.6% - for the 1,140 patients treated with uncoated devices. When the research team looked at all-cause mortality at the one-year mark, the death rates were 10.2% and 9.9% respectively. An evaluation based on clinical indication also produced no significantly different risk of death. The rates were 33.4% versus 33.1% among p...


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